Position: Data Scientist for Digital Oncology
Department: Junior Research Group Digital Biomarkers for Oncology
Code number: 2021-0295
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
So far, AI-based diagnostics have only entered clinical and especially oncological practice to a very limited extent. In the KI Translation Initiative (KTI), our interdisciplinary working group aims to optimize algorithms generated by means of deep learning as diagnostic assistance systems for clinicians in order to enable long-term "tailor-made" care for cancer patients, e.g. with malignant melanoma, breast cancer or prostate cancer. We use image analysis algorithms to analyze hematoxylin-eosin-stained tissue sections in order to enable statements about tumor properties as biomarkers.
The main focus of the project is to achieve an improved generalization ability of such algorithms on "foreign" data - for example on tissue sections from another clinic. In addition, interpretability / explainability of the "black box" CNN for the user will have to be increased in order to enhance usefulness and acceptance of such applications in the clinic. Model uncertainty will also be included in order to provide a further measure of the reliability of the diagnosis made by the algorithm. In addition, the project will also investigate whether the use of XAI methods may serve to identify new structures on histological slides that can also be detected by human observers and thus could also be employed by pathologists to examine tissue sections.
To support our team at DKFZ Heidelberg, we are looking for a data scientist to help develop and scientifically present the newly generated or improved, digital biomarkers.