In Silico Biology Scientist in Aachen bei Grünenthal

If you’re passionate about changing lives for the better, this is the opportunity you’ve been waiting for. In Research & Development, we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state-of-the-art Research & Development environment, developing innovative medicines that change the live of patients for the better and help us make progress towards our vision of a world free of pain. Join us today, and discover the difference you can make.

What the job looks like
Each day you'll enjoy a variety of challenges, such as:

• Drive implementation of innovative computational methods and techniques for identifying novel pain pathway and target insights, translational biomarkers and patient stratification
• Deliver data analytic platform to integrate single cell multiomicsfunctional genomics, patient-level data leveraging AI/ML/DL techniques to identify novel drug targets in pain
• Correlate genomic data (human genetics and functional genomic datasets) against clinical/patient phenotypic data to discover novel pain disease insights and biomarkers for response/resistance to therapy
• Present and communicate key findings to relevant stakeholders to enable data-driven decision making across research pipeline.
• Ensure findings from computational biology work are appropriately incorporated into the asset strategies and more specifically into clinical translation and early clinical development plan (CDP) for the asset
• Initiate, design and establish external collaborations anchored in in silico biologys to inform target selection, efficacy/safety assessment and de-risking of assets
• Be responsible to integrate other efforts within our research group focused on human cell-based models and systems biology

• PhD in computational biology/bioinformatics/systems biology with either postdoctoral or relevant industry experience
• Proven experience in applying computational tools and techniques to drug development, including designing successful omics strategies for drug translation
• Track record of peer-reviewed publications that apply ML/DL/AI methods and biological interpretation to single cell multiomics and omics data sets
• Demonstrated recent ability to design and lead human omics studies (with a variety of study designs) delivering novel and actionable findings with measurable impact on R&D pipeline (e.g. generated novel targets/projects that advanced to clinical stage, identification of biomarkers used in pre/clinical settings)
• Proven expertise in working with multiple omics data sets at bulk and single cell resolution
• Expert in programming with R and/or Python
• Broad experience in training and evaluating machine learning models leveraging frameworks such as Tensorflow, Keras, Pytorch
• Prior experience with high performance computing environments and cloud technology
• In depth knowledge of various external databases employed in omics & systems biology research to be able to explore their applicability for Grunenthal portfolio
• Fluent business English language skills in speaking and writing, German language skills beneficial
• Broad international & intercultural working experience

• Hybrid working model
• Bilingual daycare centre "Karlinis" and holiday activities for employees' children
• 30 holidays, plus 6-8 bridging days and possibility to convert salary into up to 5 additional holidays
(E-) Bike leasing and e-charging stations