PhD student bei Universitätsklinikum Freiburg

We focus on translational research in the field of tumor immune escape in Hepatocellular carcinoma. Our results contribute to a better understanding of tumor-immune cell interactions with implications for therapeutic strategies.

Job description:
The aim of this project is to comprehensively study the role of Wnt/β-catenin tumor cell signaling for activation and functionality of the tumor immune microenvironment in hepatocellular carcinoma using patient-derived 3D model systems and high-dimensional immune cell profiling. Your work will give insights into the potential of Wnt/β-catenin signaling as a targetable candidate pathway to improve tumor susceptibility to immunotherapy for the continuously rising number of patients with hepatocellular carcinoma.

We offer:

• a translational project in a clinically relevant setting with the possibility to implement your own ideas
• working in a dedicated interdisciplinary team of biologists and physicians on exciting research topics
• possible participation in a graduate program
• a unique network of excellent partners for continuous support in development of your scientific profile
• a good working atmosphere in modern laboratories with cutting-edge equipment
• buddy system for new doctoral researchers
• participation in a wide range of further training opportunities and participation in (inter-)national conferences
• salaries are based on the German academic standards (TV-L E13, 65 %) with attractive employee benefits, e.g. JobTicket
• an annual additional payment
• 30 days of vacation

Your work includes but is not limited to:

• autonomous processing of research tasks related to immune escape in hepatocellular carcinoma
• working with 3D ex vivo models including tumor spheroids and organoids
• application of state-of-the-art and cutting-edge methods of cell and molecular biology including immunohistochemistry, imaging mass cytometry, high dimensional FACS
• establishing of new methods to elaborate on subsequent research questions
• working with infectious sample material (S3** lab)
• presentation of results on regular lab and (inter-)national conferences
• supervision of students

Prerequisites:

• we are looking for a highly motivated and enthusiastic individual who enjoys translational scientific work in an interdisciplinary and international team
• graduation (M. Sc.) in biology, molecular medicine or related subjects preferentially with focus on oncology and/or immunology
• strong interest in translational research, human immunology and oncology
• distinct working autonomy combined with a high capacity for teamwork
• a careful and focused working habit
• enjoy scientific work
• awareness of careful documentation
• ability to work independently and as a part of an international team
• communication skills in English
• knowledge in presentation skills

If you are interested, please submit your application in German or English (including CV, a motivation letter and contact details of two references).

For further information please contact: