StartUp Science Trainee Plasmid Sciences for in vivo gene therapy in Penzberg bei Roche

Are you looking for a new scientific challenge? Do you want to take your development into your own hands and are you looking for a company where you can take on responsibility and design things creatively? Then you are right with us!

For our StartUp Science trainee program, we are hiring committed university graduates (m/f/d) with a PhD who, with vision, expertise, international orientation, curiosity and courage, implement projects relevant to our company and actively help shape changes. Is building networks on a national and international level important to you and would you like to have an experienced manager by your side as a personal mentor?

Then this is your chance!

Who we are

The Gene Therapy unit of Pharma Technical Cell and Gene Therapy (PTC) is responsible for the technical development and clinical production of breakthrough viral vector-based therapies from early clinical phase to market approval. Our core business is the development of safe, innovative and effective therapies using state-of-the-art technologies for the entire value chain.

In the new field of in vivo gene therapy, we are concentrating on the following main tasks:

• Technical development and clinical supply of viral vectors for in vivo gene therapy

• Technical development and production of plasmid DNA as a key element and starting material for in vivo gene and cell therapy

What to expect?

You will join an expert team in Pharma Technical Cell and Gene Therapy in the area of Plasmid Sciences and Plasmid Manufacturing for viral vector based therapies.

• The objective of your work is to develop and implement new technologies and cutting-edge sciences for the production and characterization of novel plasmid formats.

• You can expect multi-disciplinary and versatile projects in a highly innovative and dedicated work environment. As a member of a global team, you will work in close collaboration with colleagues from different sites of the Roche group as well as academic institutions.

• In addition to an intense training-on-the-job you can foster your own development and your career by dedicated trainee seminars and workshops.

• Development of a network through job rotations with global collaboration partners in Europe and the US and interaction with different interfaces and with current and former trainees.

Key responsibilities include, but are not limited to the following tasks:

• Leading projects to develop and implement novel plasmid formats as starting material for viral vector based therapies including independent planning and execution of experiments as well as interpretation, evaluation and documentation of development data

• Scientific evaluation, optimization and implementation of emerging cutting-edge technologies for bioprocess development and production of these plasmids

• Develop strategies to improve productivity and ensure manufacturability

• Driving the science together with a highly enthusiastic, agile and cross-functional team interacting with development experts in early research, bioprocess development and analytical development

• Execute the projects proactively with internal and external partners

• Ensure attending and presenting at scientific meetings, publication of scientific advances and interacting with the academic community

Who you are

• You hold a PhD in Chemistry, Biology, Biochemistry, Virology or in another related field with deep understanding of molecular biology technologies, plasmid design as well as bioprocess development

• You have hands on experience in the field of plasmid sciences including E. coli small scale production as well as hands-on experience with basic biochemical and molecular biology techniques

• Experience in E. coli strain engineering and demonstrated experience in the field of adeno-associated viruses (AAVs) is a plus

• Excellent problem-solving skills with a strong drive and high degree of self-motivation complete your profile

• You enjoy working in a team even in an international environment but you also have the ability to work independently with excellent planning and organizational skills

• You have well-developed communication skills in English (verbal and written) and ability to communicate with colleagues in different functions and with different background

The duration of this trainee program is set for three years.

What happens next? - How to apply?

• First we are looking forward to receiving your application with an up-to-date CV. At the moment we do not need any