PhD in Deutschland bei Universitätsklinikum Tübingen

We are studying the cross-talk between gut microbes, pathogens, the immune milieu and environmental factors in cancer development, therapy and infections.

The lab’s science mission is to understand how individual bacteria, microbial consortia or microbial perturbations through diets or antibiotics interplay with inflammatory responses and metabolic disturbances to drive carcinogenesis and metastasis preclinical models. We also study the longitudinal cross-talk of cancer therapies with the gut microbiota in patients and in mouse models to investigate causal relations, e.g., by direct bacterium-host cell interactions or via microbial metabolites. Thereby this PhD-project focuses on CAR-T cell therapies.

We are using cutting-edge wet-lab techniques combined with bioinformatic tools to sequence and to analyse the microbiome from different sites of the gastrointestinal tract applying culture-omics and high-resolution metagenome sequencing techniques. This approach is combined with multi-omics characterisation of the host’s immune system or the metabolome, and we utilize gnotobiotic model systems to infer causality in microbe-host interactions. In translational clinical approaches, we are performing clinical studies to study patient microbiomes, associations with disease and environmental factors and carry out microbiome-based interventions for the benefit of patients.

Please send your application as a single PDF file that includes: a cover/motivation letter; your CV/biosketch; contact information for two references; and university transcripts.

We offer remuneration in accordance with TV-L (collective wage agreement for the Public Service of the German Federal States), severely handicapped persons with equal qualifications are given preferential consideration. The University of Tübingen strives to hire more female scientific staff, and therefore emphatically requests women to apply for this position. Interview expenses are not covered. Please note the applicable vaccination regulations. Personnel appointments will be made pursuant to the fundamental stipulations of the legal statutes for universities in Germany.