PhD – Proteomics for personalized therapies for metabolic diseases bei Universitätsklinikum Aachen AöR

As a tertiary and quaternary level provider of medical care, the University Hospital of RWTH Aachen combines patient-oriented medicine and care, teaching and research at an international level. The entire spectrum of medical care is provided through 36 specialist departments, 33 institutes and six interdisciplinary units. The co-location of patient care, research and teaching in a central building offers the best conditions for intensive interdisciplinary exchange and close clinical and scientific networking. Highly qualified teams of doctors, nurses and scientists work collaboratively to optimise the healthcare provision of our local, regional, national and international patients. Around 9,000 employees ensure that our care delivery is patient-oriented medicine and surpasses the highest quality standards. With 1,400 beds, the university hospital treats around 50,000 inpatient and 200,000 outpatient cases per year.

The Clinic of Gastroenterology, Metabolic Diseases and Internal Intensive Care (Medical Clinic III) is seeking a

PhD (f/m/d) – Proteomics for personalized therapies for metabolic diseases

The part-time position (25,03 hours/week/65%) can start as soon as possible. The PhD position is limited to three years. More detailed information is available upon request.

Tasks:

• Analyze the impact of proteomics on the development of metabolic disease in a population-based cohort using data from the UK Biobank
• Integrate metabolomics, genomics and proteomics data, as well as patient data, to identify correlations.
• Perform statistical modeling techniques, including machine learning algorithms, to extract insights from complex datasets
• Perform data analysis and visualization to communicate findings effectively

You are:

a highly motivated and skilled PhD student to join our DFG funded research team to explore the intricate interplay proteomic signatures and metabolic diseases. The position offers an exciting opportunity to contribute to cutting-edge research in the field of biostatistics and data science, while gaining valuable experience in high-performance computing environments and contributing to improved patient outcomes.

We are looking for: Scientifically interested and motivated PhD students who would like to work on an exciting and relevant topic in our international and dynamic research team. The successful candidate can make a significant contribution to unraveling the complex relationships between diet, gut microbiota, and liver health. Together, we aim to improve our understanding of the role of nutrition in liver disease development and pave the way for future interventions.

• Bachelor's degree in a relevant field, such as Computer Science, Bioinformatics, Data Science, or a related discipline
• Strong analytical and problem-solving skills
• Excellent written and verbal communication skills in English (Level C2)
• Ability to work independently, but collaboratively in a multidisciplinary research environment
• Passion for scientific research and a keen interest in omic technologies
• Experience with High Performance Computing Environments, particularly Linux, is an essential prerequisite for this thesis. Proficiency in parallel computing, including the ability to submit jobs with Slurm, is highly desired
• Comfortable with scripting languages such as bash for automation and task management
• Extensive programming experience in Python and R, with a strong understanding of statistical modeling and data analysis. Ability to manipulate high volume and large datasets effectively
• Experience in process automation to streamline data workflows
• Willingness to learn and adapt to new biostatistics tools and techniques
• Interest in solving medical problems

We offer:

Careful and close supervision (1:1) with structured training by the project supervisor (Prof. Carolin Schneider, MD) within an established team with several

post-docs and doctoral students. The project supervisor works scientifically at the Medical Clinic III in Aachen as well as at the University of Pennsylvania.

Why should you choose us?

• 300 professions under one roof - more variety is not possible.
• We offer performance-based remuneration in accordance with the provisions of TV-L (EG 13), including attractive public service benefits.
• In addition to a wide range of further education and training opportunities we offer a wide range of health promotion options as well as the extensive university sports program.
• Monthly employee discounts through our corporate benefits program to save on private shopping.
• Flexible working hours so that you can better combine work and private life, because your work-li