PhD student Immunology – DFG funded project bei Universitätsklinikum Heidelberg

PhD student Immunology – DFG funded project (m/f/d) bei Universitätsklinikum Heidelberg

Universitätsklinikum Heidelberg

wanted for the next possible date.

The research group (head: Prof. Dr. Yvonne Samstag) investigates molecular mechanisms that control the activation and motility of immune cells in physiological and pathophysiological settings. As part of the SFB interdisciplinary collaborative research centre CRC156 ("The skin as sensor and effector organ orchestrating local and systemic immune responses"), the PhD project (CRC156-B04) aims to reveal new insights into influencing immune cell activation in allergy and chronic inflammatory skin diseases (e.g. allergic contact dermatitis and psoriasis). Particularly, it will focus on investigating and modulating the molecular mechanisms regulating the interaction between primary human keratinocytes and T cells, including application of an in vitro human skin equivalent model. Moreover, the role of actin-remodeling proteins for the function of different immune cells and their potential as therapeutic target will be analyzed by making use of knock-in and knock-out mouse models.

The aim of the project is to better understand the molecular mechanisms of inflammatory skin diseases and to identify potential therapeutic targets. The work will include a variety of biomedical and immunological research methods (e.g. in vivo mouse models, flow cytometry, confocal microscopy, biochemistry, cell biology, and molecular biology), that are largely established in the research group.

The opportunity to shape the project with own ideas and to start developing an independent scientific profile will be given and encouraged.

Job-ID:

V000011806

Field of application:

Institut für Immunologie

Location:

Heidelberg

Start date:

as of now

Job Category:

Science and teaching

Working hours:

Part time (part-time 65 %)

Published:

12.10.2023

Limitation:

Temporary (30.06.2027 - extension is sought)

Contract:

TV-L

Your Tasks

Design, implementation, and conductance of the project-related lab work (e.g. 2D in vitro coculture system, human skin equivalent models, immunohistochemistry, immunofluorescence, multi-color flow microscopy, mouse experiments)
Communication with collaborating research groups of the CRC156

Your Profile

M.Sc. degree in the field of biology or related
Basic knowledge of cell and molecular biology is required
Hands-on experience with primary cells, experience in multi-color flow cytometry and experience in working with laboratory animals are preferable
High degree of motivation, enthusiasm in research, very good organizational skills
Excellent English language skills

We offer

An exciting project in an international research group and collaborative environment
State-of-the-art research facilities
Support for your personal and career development through internal training programs at Heidelberg University, individual supervision, and participation in conferences
A competitive salary according to TV-L
Collectively agreed remuneration, attractive company pension scheme (VBL)
30 days vacation
Sustainable travel: job ticket
Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
Wide range of health, prevention and sports offers

Contact & Application

For further information, please contact Prof. Dr. Yvonne Samstag via e-mail.

Please send your full application (letter of motivation, CV, and certificates) and two reference addresses in one PDF file via e-mail to Irmgard Barnes.

Application deadline: October 15th, 2023

Institut für Immunologie
Prof. Dr. Yvonne Samstag
Im Neuenheimer Feld 305
69120 Heidelberg
Tel.: 06221 56-310998
yvonne.samstag@urz.uni-heidelberg.de

Please note that the UKHD is subject to the provisions of the Infection Protection Act. Therefore, valid proof of measles immunity is required for all persons employed at the UKHD.

We stand for equal opportunities. Severely disabled persons are given priority in the case of equal suitab