Universitätsklinikum Heidelberg
wanted for the next possible date.
The research group (head: Prof. Dr. Yvonne Samstag) investigates molecular mechanisms that control the activation and motility of immune cells in physiological and pathophysiological settings. As part of the SFB interdisciplinary collaborative research centre CRC156 ("The skin as sensor and effector organ orchestrating local and systemic immune responses"), the PhD project (CRC156-B04) aims to reveal new insights into influencing immune cell activation in allergy and chronic inflammatory skin diseases (e.g. allergic contact dermatitis and psoriasis). Particularly, it will focus on investigating and modulating the molecular mechanisms regulating the interaction between primary human keratinocytes and T cells, including application of an in vitro human skin equivalent model. Moreover, the role of actin-remodeling proteins for the function of different immune cells and their potential as therapeutic target will be analyzed by making use of knock-in and knock-out mouse models.
The aim of the project is to better understand the molecular mechanisms of inflammatory skin diseases and to identify potential therapeutic targets. The work will include a variety of biomedical and immunological research methods (e.g. in vivo mouse models, flow cytometry, confocal microscopy, biochemistry, cell biology, and molecular biology), that are largely established in the research group.
For further information, please contact Prof. Dr. Yvonne Samstag via e-mail.
Please send your full application (letter of motivation, CV, and certificates) and two reference addresses in one PDF file via e-mail to Irmgard Barnes.
Application deadline: October 15th, 2023
Please note that the UKHD is subject to the provisions of the Infection Protection Act. Therefore, valid proof of measles immunity is required for all persons employed at the UKHD.
We stand for equal opportunities. Severely disabled persons are given priority in the case of equal suitab
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