Two PhD positions bei Universität Heidelberg

Two PhD positions “Centriole regulation in health and disease” (f/m/d)

Centre of Organismal Studies (COS) and Centre for Molecular Biology (ZMBH) Heidelberg University, Germany

We are seeking for two motivated PhD students interested in basic and applied centriole research related to human disease.

The centriole is a microtubule-based structure that is important for mitotic spindle formation and assembly of the primary cilium, an essential signalling organelle. Duplication, length and structure of centrioles are highly regulated by a protein network, represented by the protein CEP350, which prevents centriole overduplication, over-elongation or fragmentation. Defects in this network are the cause of inherited disease and are linked to cancer.

This project combines the expertise of the Pereira and Schiebel laboratories in cilia formation and centriole biology. It aims to understand the function and regulation of the CEP350 network and how its malfunction leads to disease. The project involves genome editing, the use of protein degrons for the rapid depletion of proteins, phospho-proteome analysis, and advanced microscopy (live cell image, ultra-expansion and electron microscopy).

Applicants should have a strong background in cell or molecular biology and a special interest in centrosome and cilia formation. One student will work in the Pereira lab at COS and the other in the Schiebel lab at the ZMBH. Both PhD students will be members of the Heidelberg Biosciences International Graduate School (HBIGS) www.hbigs.uni-heidelberg.de/.

We offer:

The PhD position is funded in the first instance for 3 years with starting date based on mutual agreement (possible from January 2024). Renumeration is based on TV-L E13. Application deadline: 31.12.2023

Interested?

Please send applications (CV, motivation letter, 2-3 referees and a copy of Bachelor and Master transcripts) to both, Gislene Pereira gislene.pereira@cos.uni-heidelberg.de and Elmar Schiebel e.schiebel@zmbh.uni-heidelberg.de. Mailing address: Prof. Elmar Schiebel, ZMBH, Heidelberg University, Im Neuenheimer Feld 345, D-69120 Heidelberg, Germany. We ask for your understanding that application documents received will not be returned.

For literature on this topic, please follow this link to our website:

www.zmbh.uni-heidelberg.de/schiebel/open.html

Heidelberg University stands for equal opportunities and diversity. Qualified female candidates are especially invited to apply. Persons with severe disabilities will be given preference if they are equally qualified. Information on job advertisements and the collection of personal data is available at www.uni-heidelberg.de/en/job-market.