PhD Student – Characterizing Pathways involved in Anti-Cancer Therapy Response in Berlin bei Deutsches Krebsforschungszentrum

Deutsches Krebsforschungszentrum

Position: PhD Student – Characterizing Pathways involved in Anti-Cancer Therapy Response

Department: DKTK partner site Berlin - Charité Universitätsmedizin Berlin, Molecular Epidemiology Unit at BIH

Code number: 2023-0359

The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.

Together with university partners at seven renowned partner sites, we have established the German Cancer Consortium (DKTK).

For the DKTK partner site Berlin we are seeking a PhD student to join the Molecular Epidemiology Unit at the Berlin Institute of Health at Charité-Universitätsmedizin Berlin.

The candidate will support the unit in the research project PredictAHR. The PredictAHR project utilizes existing data from the German Cancer Consortium of the tumor entities malignant melanoma, glioma, sarcoma, lung cancer and chronic lymphocytic leukemia and prospectively collects samples that are profiled using high-throughput methods. Our goal is to identify and validate pathways downstream of AHR that modulate therapy response. PredictAHR will investigate the predictive power of the AHR signature in various cancers and develop assays for AHR activity that can be integrated into the clinic.

Job description:

Cell culture: thawing, culturing, splitting, and freezing of cells; functional in vitro analyses
Molecular biology / protein chemistry: PCR, RT-PCR, qRT-PCR, DNA and RNA isolation, protein isolation, Western blot, gene-knockdown
NGS including scRNA sequencing and ChIP sequencing
Planning and execution of (cell culture) experiments
Statistical evaluation of results
Bioinformatics analyses (NGS data)
Documentation and evaluation of research results as well as preparation of publications, lectures, posters
Preparation of the dissertation within the PhD project

Requirements:

University degree (Master / Master of Science) in biology, chemistry, biochemistry or comparable of at least 8 semesters
Knowledge in cell culture techniques of human cell lines, primary cells (organoid cultures would be desirable)
Experience in bioinformatics analyses (knowledge of R or similar)
Knowledge of basic immunological and molecular biology techniques
High degree of independence, motivation and interest in the development of modern methods and their application in cancer research

We offer:

Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
Access to international research networks
Doctoral salary with the usual social benefits
30 days of vacation per year
Flexible working hours
Possibility of part-time work
Family-friendly working environment, e.g. parent-child room, advisory services
Sustainable travel to work: subsidized Germany job ticket
Unleash your full potential: targeted training and mentoring through the DKFZ International PhD Program and DKFZ Career Service
Our Corporate Health Management Program offers a holistic range of services for your well-being

Important notice:

The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles may work at the DKFZ.

Earliest Possible Start Date: as soon as possible

Duration: The position is limited to 3 years.

Application Deadline: 08.11.2023

Contact:

Dr. Anja Hümpel
Phone +49 (0)30/450 564 656

Please note that we do not accept applications submitted via email.

The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.

Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (https://www.dkfz.de/en/stellenangebote/index.php).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.