PhD candidate for “Characterization of protein cleavage in regulated cell death” bei Universität Freiburg

Our team studies biological signaling and protein function with a focus on proteolysis on a proteome-wide scale using mass spectrometry. As part of the SFB1403 (www.sfb1403.uni-koeln.de), we are using termini enrichment approaches to identify new proteolytic processing events and their function in regulated cell death (RCD). The project further aims to deconvolute the activities of different caspases in distinct RCD pathways using optogenetic tools.

Your tasks

• Develop innovative proteomics methods: Adapt and improve biochemical protocols for termini enrichment, including implementation on a liquid handling system.
• Identify and deconvolute substrates of optogenetically controlled caspases in RCD.
• Contribute to mass spectrometry operation and maintenance.
• Proactively communicate and interact with project partners in the SFB1403.
• Document, present and discuss your results at scientific conferences and as peer-reviewed publications.

Your profile

• Master´s degree in biochemistry, biology, or related area.
• Hands-on experience in biochemistry, molecular biology and cell culture.
• Experience in protein analytics, proteomics and/or mass spectrometry.
• Knowledge of R, python or similar scripting languages are advantageous.
• Motivation and willingness to learn, self-organization and team player skills.
• Fluency in English is essential, German is beneficial.

Our offer

• An interesting multifaceted position with high personal responsibility.
• A motivated, collaborative team with supportive working atmosphere.
• Access to state-of-the-art experimental facilities and mass spectrometry equipment.
• A structured training program with supervision by a thesis advisory committee.
• Further training opportunities and participation in research conferences.

Please submit your application, including a cover letter with brief description of motivation (1 page), your CV, M.Sc. and B.Sc. certificates with transcripts of record and contact details of two referees, as a single pdf file.