Deutsches Zentrum für Neurodegenerative Erkrankungen
The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine. www.dzne.de
The group of Dr. Daniele Bano investigates molecular mechanisms underlying aging and neurodegenerative diseases. They study metabolic adaptations that can promote the longevity of animals carrying mitochondrial lesions (Piazzesi A. et al, 2022; Jackson J. et al, 2022; Gioran A. et al, 2019; Piazzesi A. et al, 2016; Gioran A. et al, 2014). In the context of neurodegeneration, they explore how gene-by-environment interactions can influence the phenotypic outcomes of pathogenic variants (manuscripts in preparation; Bertan F. et al, 2021; Wischhof L. et al, 2018; Troulinaki K. et al, 2018; Meyer K. et al, 2015). As an additional line of their research, they have recently uncovered novel signaling pathways that define cell lineage commitment and differentiation by priming mitochondrial bioenergetics in a transcription-dependent manner (Wischhof L. et al, 2022; Wischhof L. et al, 2017).
The team is looking for a highly motivated and science-driven scientist fully committed to develop further their ongoing projects. Taking a mitochondria-centered approach, the new team member will also develop new Caenorhabditis elegans models of human disorders for which the molecular mechanisms underlying the neurodegenerative processes have not been fully elucidated yet. The groundwork of this project builds on some of their recent unpublished findings. Besides C. elegans, the new team member will work also with iPSC-derived neurons, microglia and cerebral organoids, for which all protocols and methods are available in the laboratory.
Academic Staff Member (f/m/d) Potsdam Vollzeit Universität Potsdam EMBL CPP Visitor Fellowships (for external PhDs and postdocs) Deutschland Vollzeit European Molecular Biology Laboratory Research Group Leader “Wireless Connectivity” (m/f/d) Dresden Vollzeit Barkhausen Institut gGmbH von MINTsax.de
Academic research assistant (m/f/x) Saarbrücken Vollzeit Universität des Saarlandes Doktorand (w/m/d) Leipzig Vollzeit German Centre for Integrative Biodiversity Research (iDiv)