Postdoctoral Researcher in Bonn bei Deutsches Zentrum für Neurodegenerative Erkrankungen

The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine. www.dzne.de

Postdoctoral Researcher (f/m/x)

Code: 1242/2023/9

Your tasks

The group of Dr. Daniele Bano investigates molecular mechanisms underlying aging and neurodegenerative diseases. They study metabolic adaptations that can promote the longevity of animals carrying mitochondrial lesions (Piazzesi A. et al, 2022; Jackson J. et al, 2022; Gioran A. et al, 2019; Piazzesi A. et al, 2016; Gioran A. et al, 2014). In the context of neurodegeneration, they explore how gene-by-environment interactions can influence the phenotypic outcomes of pathogenic variants (manuscripts in preparation; Bertan F. et al, 2021; Wischhof L. et al, 2018; Troulinaki K. et al, 2018; Meyer K. et al, 2015). As an additional line of their research, they have recently uncovered novel signaling pathways that define cell lineage commitment and differentiation by priming mitochondrial bioenergetics in a transcription-dependent manner (Wischhof L. et al, 2022; Wischhof L. et al, 2017).

Requirements

The team is looking for a highly motivated and science-driven scientist fully committed to develop further their ongoing projects. Taking a mitochondria-centered approach, the new team member will also develop new Caenorhabditis elegans models of human disorders for which the molecular mechanisms underlying the neurodegenerative processes have not been fully elucidated yet. The groundwork of this project builds on some of their recent unpublished findings. Besides C. elegans, the new team member will work also with iPSC-derived neurons, microglia and cerebral organoids, for which all protocols and methods are available in the laboratory.

We offer

• An interesting and challenging task in a research center that works on the future topics of health research
• Committed mentorship and access to a targeted career development
• A company pension plan as well as health management
• A full funded research project, initially limited to two years with the option for extension
• Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst – TVöD Bund).