Research assistant, Postdoc bei Universitätsklinikum Düsseldorf

Research assistant, Postdoc (m/f/d) bei Universitätsklinikum Düsseldorf

Universitätsklinikum Düsseldorf

Düsseldorf University Hospital (UKD) is the largest hospital in the state capital and one of the most
important medical centers in North Rhine-Westphalia. The 9,300 employees at UKD and its
subsidiaries are committed to treating over 45,000 inpatients and 270,000 outpatients every year. The
UKD stands for international excellence in patient care, research and teaching, as well as for
innovative and safe diagnostics, therapy and prevention. Patients benefit from the intensive
interdisciplinary cooperation between the 60 clinics and institutes. The particular strength of the
University Hospital is the close integration of clinical and research work for the safe application of new
methods. Tomorrow's medicine is being created at the UKD. Every day.

The Institute of Pathology of the University Hospital Düsseldorf is looking for a temporary position
from 01.01.2025 until 31.08.2027 for a

Research assistant, Postdoc (m/f/d)

The initial appointment will be for the duration of the project, with the option of extension. These are
qualification positions within the meaning of the German Academic Fixed-Term Contract Act
(Wissenschaftszeitvertragsgesetz, WissZeitVG, according to § 2 para. 1).

In a gynaecopathological project, we are investigating the organization of the microenvironment both
morphologically and functionally by comparing endometriosis and tumour pathology. The project is
intended to accompany the ENDOFERT project of the BMBF, which is initially limited until 31.08.2027.

The project combines molecular pathology techniques with digital pathology techniques. Biomarkers of
epithelial-mesenchymal transition (EMT), which can be influenced differently against the background
of different molecular subtypes, are regarded as essential functional parameters. In addition, aspects
of immunomodulation are also analyzed.

Your tasks:
• Analysis and annotation of digitized histological slides in QuPath and development of scripts for

digital image analysis

Isolation of DNA and RNA samples from FFPE and cryo material
Determination of POLEmut cases by Sanger sequencing and/or NGS analysis
Application of laser capture microdissection to precursor lesions.
Establishment of functional cell culture models for immunological and therapeutic effects in

POLEmut, POLEwt and induced POLEloss models

Alternatively, knowledge in the establishment and configuration of convolutional neural networks for

AI development.

Collaboration in biobank-related project work.Support medical students in study design and data

analysis

Collaboration with international partners
Quality control and preparation of SOPs in the laboratory
Basic bioinformatics data analysis of sequencing data

Your profile:
• Completed university studies (M.Sc./M.A./Diploma) in life sciences, natural sciences or a comparable

discipline with doctoral degree

Experience in histological techniques, nucleic acid extraction methods and sequencing
Strong computer skills, including script programming (e.g., Python, R, C/C++)
Experience in wet lab projects (e.g., cell culture)
Experience in project management
Excellent oral and written communication skills in English
Strong ability to work in a team

We offer:
• A collaborative work environment in a fresch and innovative team

Well equipped laboratory and office space

The opportunity to join the Heine Research Academies (HeRA) for professional development and

networking, to participate in mentoring programs, and to receive support for research funding and
travel expenses

An exciting and diversified position in a pleasant working atmosphere
Family-friendly working environment, for example with a day care center for children
Discounted employee ticket
Staff accommodation/apartment
Depending on the applicant's personal qualifications, the position will be grouped according to

collective bargaining agreements up to pay group 13 TV-L.

Your contact person for technical questions is Prof. Dr. Tilman Rau, Tilman.Rau@med.uni-
duesseldorf.de;

Remuneration is in accordance with the provisions of the TV-L in pay group 13.
The employment contract is concluded with the Heinrich-Heine-University Düsseldorf.

Severely disabled applicants will be given preferential consideration in case of equal suitability.

By sending the application documents, the applicant agrees that th