Research fellow in Halle (Saale) bei Martin Luther Universität Halle Wittenberg

External Job Announcement Reg.-Nr. 5-5524/24-D

The Martin Luther University Halle-Wittenberg, Faculty of Natural Sciences III invites applications for the

position of a

Research fellow (m/f/d)

in the DFG-funded Collaborative Research Centre (CRC) SNP2Prot "Plant Proteoform Diversity".

The position is funded from 1 October 2024 to 30 June 2028 in full time (100 %). Salaries will be according

to Entgeltgruppe 13 TV-L depending on the assigned tasks and individual qualifications.

Tasks:

• Bioinformatics research within the framework of the SNP2Prot subproject D02 Development of SNPstar 2.0

and computational prediction of putative proteoform candidates with high functional proteoform variation.

• Development of a Plant Pangemome Browser for constructing, visualising, and analysing pangenomes of

diploid and polyploid monocots and eudicots including Arabidopsis, barley, wheat, rice, maize, and tomato.

• Development of bioinformatics and machine learning approaches for

• computing, visualising, and analysing orthology relationships between genes, promoter regions, and

intergenic regions within and between these pangenomes based on the conservation of protein se-

quences, gene structures, and their genomic context;

• integrating, visualising, and analysing sequence and 3D-structure data for elucidating the effects of nat-

urally occurring SNPs and ‘designer’ mutations in protein coding genes for predicting functionally modi-

fied proteoforms;

• integrating, visualising, and analysing DAP-seq data, GHT-SELEX data, ChIP-seq data, RNA-seq data,

other omics data, and 3D-structural data for elucidating the effects of non-coding SNPs in and near pu-

tative transcription factor binding sites.

• Presentation and publication of scientific data and methods

The opportunity to obtain your own academic qualification as part of a habilitation or doctorate is given.

Requirements:

• An excellent MSc degree (or equivalent) in bioinformatics, computational biology, computer science, or a

closely related discipline

• A strong interest in analysing, visualising, and elucidating the effect of natural variations and ‘designer’ mu-

tations on a pangenome level

• PhD experience in bioinformatics and publication experience in bioinformatics are considered a strong plus

• Expertise in the analysis of sequence data with bioinformatics methods and machine learning is considered

a plus

• Solid programming skills at least in Java and R, expertise in algorithm development, software development,

and database design

• Excellent English language skills (active and passive, written and spoken)

• Highly motivated to work in this central bioinformatics position with its freedom and opportunity to collab-

orate closely with any of the research groups of the CRC and our international partners in Europe and

North America

For application use the online application form at https://blogs.urz.uni-halle.de/snp2prot/. The submission

deadline is July 15th, 2024.

veröffentlicht 21.06.2024

In case of queries concerning the application process or project-related questions please contact:

info@snp2prot.uni-halle.de, Tel.: +49 345 55-24834, or the PIs of the project Prof. Dr. Marcel Quint

(marcel.quint@landw.uni-halle.de, Tel.: +49 345 5522739) and Prof. Dr. Ivo Große

(ivo.grosse@informatik.uni-halle.de, Tel.: +49 345 5524774).

The Martin Luther University Halle-Wittenberg gives priority to applications from severely disabled candidates

with equivalent qualification. Women are particularly encouraged to apply. Applicants with a foreign qualification

have to show the statement of comparability for foreign higher education qualifications issued by Central Office

for Foreign Education|Zentralstelle für ausländisches Bildungswesen (https://www.kmk.org/zab/central-office-

for-foreign-education).

This call for applications is subject to possible budgetary restrictions.

Application costs will not be reimbursed by Martin Luther University. Only applications submitted via the appli-

cation web form (https://blogs.urz.uni-halle.de/snp2prot/) can be accepted.

veröffentlicht 21.06.2024