Scientist* Ex vivo T-cell engineering in Mainz bei BioNTech AG

Become a member of the BioNTech Family!

As a part of our team of more than 5.000 pioneers, you will play a key role in developing solutions for some of the most crucial scientific challenges of our age. Within less than a year, we were able to develop our COVID-19 mRNA vaccine following the highest scientific and ethical standards – writing medical history.

We aim to reduce the suffering of people with life-changing therapies by harnessing the potential of the immune system to develop novel therapies against cancer and infectious diseases. While doing so, we are guided by our three company values: united, innovative, passionate. Get in touch with us if you are looking to be a part of creating hope for a healthy future in many people's lives.

• Independent planning, design and execution of experiments aiming to develop genome engineering tools and procedures; development of novel assays and procedures for detailed characterization of engineered cells
• Working actively with research specialits in the lab, organizing and supervising research specialists experimental work and documentation, review of generated experimental results; making sure that all ascpects of the required experimnetal work are completed
• Analyzing, interpreting, preparing and documenting experimental results; presentation of results in a concise, understandable, and focused manner within a team of experts, associated subject matter experts or scientific conferences; support in writing of IP and regulatory documents as well as SOPs
• Regular reporting to associate director and higher management. Working closely with associate director to define priorites and timelines and ensure the execution of the set goals
• Participation in department and project team meetings and work effectively with other functions to ensure alignment cross-functionally; communication with internal and external collaborators and business partners

• Completed doctorate in the field of immunology, cancer immunology, biomedicine, or comparable qualification
• Minimum 3 years of experience in T-cell engineering for cancer immunotherapies or relevant biomedical research experience in engineered immune cell therapy
• Extensive experience in immune cell cultures, immunoassays for CAR/TCR T-cell product characterization (e.g., cytotoxicity assays, cytokine profiling, proliferation assays) and multicolor flow cytometry-based assays and analysis
• Experience with non-viral and viral genome engineering technologies, and delivery tools to modify primary immune cells. Experience with DNA transposons is an advantage.
• Experience with CliniMACS Prodigy or Lonza Cocoon systems is advantage
• Experience with in vivo characterization of CAR T cells in murine tumor models and having FELASA certificate is an advantage
• Previous experience with generating data packages for clinical translation is an advantage
• Scientifically self-motivated, goal-oriented and experienced in independently planning, conducting, and analyzing own research with minimal supervision.
• Experience in multitasking and working in a fast-paced environment
• Experience in supervision of technical staff and/or students.
• Experience in Pharma/Biotech industry is an advantage.
• Experience in working with interdisciplinary cross- functional teams.
• Excellent spoken and written English language skills.

• Flexible Working Time
• Mobile Office
• Work from EU Countries
• Company Pension Scheme
• Childcare
• Jobticket
• Company Bike
• Leave Account
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