PhD Student for “Improved C-terminomics for protease substrate discovery” bei Universität Freiburg

Our team (www.proteasedegradomics.org) studies biological signaling and protein function on a proteome-wide scale using mass spectrometry. A major focus of our research are dynamic proteolytic processes regulating protein abundance, function and interactions, with broad relevance in for biomedicine and bioeconomy. In this project we aim to systematically improve established procedures for C-terminome analysis and apply them for protease and carboxypeptidase substrate discover with partners in the research training group GRK2606. (https://www.protpath.uni-freiburg.de)

We offer:

• An interesting multifaceted position with high personal responsibility
• A motivated, collaborative team with supportive working atmosphere
• A structured training program with professional supervision by a thesis advisory committee
• Further training opportunities and participation in research conferences

Your tasks

• Develop innovative proteomics methods: Adapt and improve biochemical protocols for C-termini enrichment, contribute to develop alternative approaches
• Profile C-terminal processing as a PTM in clinically relevant samples
• Identify substrates of clinically relevant proteases and carboxypeptidases
• Help to the operation and maintenance of state-of-the-art nanoLC-MS/MS systems
• Proactively communicate and interact with project partners in the GRK2606
• Document, present and discuss your results at scientific conferences and as peer-reviewed publications

Your profile:

• Master´s degree in biochemistry, chemistry, biology, or related subject area
• Proven experience in biochemistry, ideally also in proteomics / mass spectrometry
• Knowledge of R, python or similar scripting languages are advantageous
• High proficiency in English (written and oral)
• Motivation, self-organization and team player skills