Postdoc/ Immunologist – CECAD (KHS-32355) bei Universitätsklinikum Köln

Postdoc/ Immunologist (f/m/x) – CECAD (KHS-32355) bei Universitätsklinikum Köln

Universitätsklinikum Köln

Beschreibung

» Your tasks

Use cell lines and mouse models to investigate the intersection between immunity, metabolism and inflammation
Use immunology, biochemistry, and computational techniques to investigate metabolism at the molecular level in immune cells
Perform multi-omics analyses (metabolic, proteomic and transcriptomic studies) and integrate these datasets to generate new hypotheses
To accurately record and judiciously analyse, present, and report experimental data
Drive your own research project under the supervision of the PI
Interact and train junior members and technicians in the lab

The Postdoc project of the successful candidate will be part of a unique and novel multidisciplinary consortium on “Immunometabolism in Health and Disease (iHEAD)”. This consortium investigates the intersection between immunity, metabolism and inflammation. The candidate will work specifically on the role of nucleotide metabolism in the activation of macrophages.

» Your Profile

A PhD in biology, biochemistry, immunology or equivalent is essential
Established experience in cellular metabolism or immunology is essential
Knowledge of research procedures and statistical methods is essential
The ability to work effectively in a team is a prerequisite
Experience in mouse models is desirable. The candidate needs to hold an animal license and have experience in writing animal protocols
A research background in immunometabolism is a plus
Proficiency in written and spoken English is mandatory
Evidence of great communication skills, curiosity-driven science and excellent problem-solving skills is essential

» Our Offer

A varied job in a highly interesting and challenging research topic
A fair working environment with appreciative cooperation
Possibility to develop side projects according to personal interests
Internal and external training opportunities
Flexible working time models to support family life
Occupational health management offers

» Your future in detail

CECAD is an inclusive, equal opportunity employer that offers attractive conditions and benefits commensurate with an international research organization with a very collegial and family-friendly work environment.

The Frezza laboratory (https://frezza.cecad-labs.uni-koeln.de) seeks to understand the contribution of dysregulated metabolism to ageing-associated disorders, focusing on cancer. A part of the lab is investigating how the loss of the mitochondrial enzyme and tumour suppressor Fumarate Hydratase causes renal cancer. Our work has multiple implications: (1) it will provide a mechanistic understanding of the role of metabolism and small molecule metabolites in human diseases; (2) it will generate experimental and computation tools to identify metabolic vulnerabilities that we can use as pharmacological targets for cancer therapy; (3) it will apply metabolomics and multi-omics analyses, to mouse and human models to identify metabolic markers of disease initiation for clinical application in early detection and for patient stratification.