The Center for Regenerative Therapies Dresden (CRTD), an institute of the Center for Molecular and Cellular Bioengineering (CMCB), is a research center with currently over 20 research groups. The research focus of CRTD lies in regeneration and stem cell research from fundamental research to clinical-translational applications in the areas of hematology/immunology, diabetes, neurodegenerative diseases, and bone and tissue regeneration. For TUD Dresden University of Technology diversity is an essential feature and a quality criterion of an excellent university. Accordingly, we welcome all applicants who would like to commit themselves, their achievements and productivity to the success of the whole institution.
Research Associate / Bioinformatician (m/f/x)
At the CRTD, the Chair of Stem Cell Research with focus on cell-based approaches to regenerative biomedicine (Prof. Dr. Michael Sieweke) offers a project position as
Research Associate / Bioinformatician (m/f/x)
(subject to personal qualification employees are remunerated according to salary group E 13 TV-L)
starting as soon as possible. The position is limited until March 31, 2025 with the option of extension in follow-up projects for up to further three years. A longer-term employment is explicitly desired. The period of employment is governed by § 2 (2) Fixed Term Research Contracts Act (Wissenschaftszeitvertragsgesetz - WissZeitVG).
We study how immune cells, especially macrophages, influence regeneration, aging, and cancer. In this context we investigate how gene regulatory mechanisms and long-term epigenetic changes control self-renewal, activation, aging and "trained immunity" (e.g., PMID: 35210623, PMID: 32169166, PMID: 26797145). The group employs molecular, genetic, genomic, and bioinformatic analyzes in human and mouse cells.
- OMICs and NGS data analysis, including RNA-Seq, ATAC-Seq, ChIP-Seq, single-cell RNA-Seq and ATAC-Seq, DNA methylation data analysis, pathway analysis, multivariate analysis.
- You will drive research questions forward and develop your own solutions, drawing from extensive in-house or public datasets.
- You will collaborate closely with other experimentally oriented researchers.
- You will be involved in the development, establishment, and expansion of new analytical methods.
university degree in bioinformatics or related subject field; profound experience in OMICs and NGS data analysis as well as advanced knowledge in statistics (with an emphasis on SIMCA-P and/or SPSS); sound knowledge of RNA-Seq, ATAC-Seq, ChIP-Seq, single cell RNA-Seq and ATAC-Seq as well as DNA methylation data analysis; sound experience in relevant software packages, programming languages and in the Linux/Unix environment. Knowledge in using current tools for generating pathway, single cell analysis, heatmap and multivariate analysis outputs (uMAP, tSNE, PCA, Clusteranalyse, K-mean Clustering, etc.) are desirable. A theoretical basis in molecular biology, sequencing technology and gene regulation is advantageous. Experience in spatial transcriptomics is a plus. You should enjoy interaction with experimental scientists to adapt available analysis methods to specific questions and optimize bio-informatic analysis and experimental design in a re-iterative process.
- work in an exciting research environment with medically relevant projects potentially leading to new therapies against cancer and other incurable diseases
- outstanding research environment with the possibility to Interact with other bioinformaticians in genomics, systems biology, and artificial intelligence institutions.
- implement your own ideas and engage in diverse work in a friendly, international team
- flexible working hours and access to childcare in close proximity to the institute
- further education and individual training programs e.g. through Cluster4Future SaxoCell
- access to TUD's university sports facilities, health promotion services and pension plan
- additional pension scheme (VBL)
- collaboration with a start-up company emerging from our academic research.
TUD strives to employ more women in academia and research. We therefore expressly encourage women to apply. The University is a certified family-friendly university and offers a Dual Career Service. We welcome applications from candidates with d