UKE - Universitätsklinikum Hamburg-Eppendorf
Better together. For life.
We are the University Medical Center Hamburg-Eppendorf (UKE) - and we stand for excellent competence in research, teaching and comprehensive healthcare in our clinics. Every day, our approximately 14.900 employees strive anew to make the world a little healthier with their contribution.
It is our aspiration to be one of the leading university hospitals - and at the same time the best employer in our industry. At UKE, for example, we firmly believe that successful and fulfilling work should be in harmony with employees' personal needs and individual lifestyles. And as diverse as these are, so is our range of individual solutions.
Welcome to the UKE.
Primary sclerosing cholangitis (PSC) is an enigmatic liver disease characterized by a chronic inflammation leading to scarring and obliteration of intra- and extrahepatic bile ducts. There is no licenced pharmacological treatment with a proven benefit on the disease course, leading PSC as major cause for liver transplantation in the western world. The disease pathogenesis is largely unknown but it is widely believed that PSC is an immune mediated disease. The mechanisms causing misguided immune cell differentiation are poorly understood but several genome-wide association studies (GWAS) have associated PSC to polymorphisms related to immune cell- and particularly T cell-function. Within this project, we aim to decipher the impact of genetic risk factors on immune cells differentiation and function. We will investigate immune cell activation, regulation and interaction with a focus on disease- associated polymorphisms. Existing and newly generated data from people with PSC will be examined to reveal signaling pathways and cellular interactions. State of the art techniques such as spectral flow cytometry, single cell sequencing and spatial transcriptomics as well as human organoid cultures will enable the identification of new therapeutic targets.
Your tasks
The application can only be considered if there is complete proof of immunisation or immunity against the measles virus in accordance with the applicable (legal and medical) requirements (at the latest by the start of employment). We kindly ask you to enclose such proof with your application documents.
Bettenbelegungskoordinator:in (all genders) (KHS-32506) Hamburg Teilzeit/Ausbildung UKE Hamburg Ärztliche:r Mitarbeiter:in (all genders) – iSTAR Advanced Clinician Scientist (ACS) (KHS-32000) Hamburg Vollzeit UKE Hamburg Doktorand:in/PhD (all genders) Eppendorf Teilzeit/Ausbildung UKE - Universitätsklinikum Hamburg-Eppendorf
Ph.D. Student (Research fellow junior) (all genders) Research Institute Children’s Cancer Center Hamburg, research group Developmental Neurobiology and Paediatric Neuro-oncology Eppendorf Vollzeit UKE - Universitätsklinikum Hamburg-Eppendorf PhD position (f/m/d) in deep learning for biomedical image analysis Eppendorf Vollzeit UKE - Universitätsklinikum Hamburg-Eppendorf