The Chair of Endocrinology and Diabetology at the University Hospital of Würzburg has a vacancy for a scientific PhD student in the research group of PD Dr. Dischinger for three years, starting January 1, 2024, as part of a collaborative project between Endocrinology and the Comprehensive
Heart failure
Center Wuerzburg (CHFC). The funding is provided by the German Research Foundation (
DFG
). The aim of the work is to further elucidate the pathophysiological relationships between obesity and
Heart failure
with preserved ejection fraction (with special attention to
mitochondrial
energy production and calcium balance) and to analyze drug therapy options in an established animal model (animal experiment already approved). The topic combines endocrinology and cardiology in an innovative way and provides an excellent basis for further scientific activity. It highlights established (GLP-1 analogues, SGLT-2 inhibitors) and experimental (PYY) therapeutic options for obesity. The aim is a comprehensive analysis of the heart by means of highly specific methods (Oroboros, Seahorse) on the one hand and other organs involved in the provision/processing of different energy carriers (liver, adipose tissue depots) on the other hand.
ALL
steps are well established in the participating institutions. The animal experimental approach allows a detailed and comprehensive analysis of cardiac function/energetics as well as a variety of other organs compromised in obesity. Animal experimental experience, which then also enables
in vivo
analytics (e.g. using echo), is desired but not a prerequisite. For further information about the working group www.ukw.de/medizinische-klinik-i/endokrinologie/forschung/experimentelle-adipositasforschung/ or contact us: dischinger_u@ukw.de