PhD student genome instability and DNA repair bei Universitätsklinikum Köln AöR

Universitätsklinikum Köln AöR

as soon as possible
part-time (25 hours / week); initially limited for 3 years (third-party funded project)
Your salary will be based on TV-L
» Your tasks

The Jachimowicz lab "Mechanisms of DNA Repair” investigates how defective DNA repair rewires ageing- and cancer pathways. The occurrence of premature ageing and DNA repair defects in human genome instability syndromes creates a unique opportunity to identify and investigate novel components of DNA repair pathways. Furthering our understanding of the mechanisms underlying novel genome instability syndromes allows us to examine their crucial role in ageing and cancer. We apply a multidisciplinary approach combining genetics, cell and molecular biology, imaging, biochemistry, mass spectrometry and modern mouse genetics, that will ultimately lead to genetically-informed therapies for patients suffering from cancer. The focus of our genome instability team lies on proteins of the Ubiquilin family and their particular role in the maintenance of DNA repair pathways. Loss-of-function mutations in UBQLN4 influence the balance between homologous recombination and non-homologous end joining (Jachimowicz et al., 2019, Cell) – but how exactly the different ubiquilins act within the protein network of DNA repair has yet to be elucidated.

Your tasks include, but are not limited to, in vitro studies of the ubiquilin family members to find out how ubiquilins are recruited to their target proteins and subsequently facilitate their degradation. You will investigate this by using our available panel of genetically modified mammalian cell lines and state-of-the-art molecular biology methods. Work with mouse models is not mandatory but would be possible.

We seek a highly motivated and talented scientist to join our enthusiastic and collaborative team in an outstanding scientific environment to take part in our exciting research.

» Your Profile

Applicants should have a Master‘s degree and a solid background in molecular biology, cell biology, genetics, biochemistry, or bioinformatics. Experience in the field of genome instability or DNA biology is a plus. The applicant should have a keen interest in DNA repair mechanisms and cancer. The working language is English; knowledge of German is not required.

Please submit your application including a detailed CV, list of publications, two references and a brief statement of research interests.

» Our Offer

We offer a great work environment, intensive mentoring and several interactions with global leaders. Our dynamic group is located at the Max-Planck Institute for Biology of Ageing (MPI-Age), which is equipped with state-of-the-art technology and excellent core facilities. The institute provides outstanding research opportunities for its scientists. At the moment, we host employees from more than 35 different nations worldwide.

» Your future with us

Working at the University Hospital Cologne and the Medical Faculty means helping to shape the future - the future of medicine, of patients and, of course, your own future. You benefit from 60 clinics and institutes as well as numerous other departments and facilities and more than 12,000 jobs. The Faculty of Medicine of the University of Cologne and the University Hospital Cologne assume important social tasks in research, teaching and patient care. A close network with many university and non-university partners guarantees an internationally successful science and the excellent education of our students.

» Your future in detail

You will analyze molecular mechanisms underlying role of ubiquilin proteins in DNA repair lymphomas in a small, interdisziplinary team of dedicated scientists and clinicians. You will be able to learn a wide range of methods, from basic biochemistry techniques and cell culture to working with mouse models. We link basic research and the application of new findings with translational research.

Applications from female candidates are expressly welcome and will be given priority in the event of equal suitability, competence and professional performance.

People with disabilities are welcome to apply and will be treated preferentially in the event of equal suitability and qualification.

Contact:
Dr. Melanie Thelen
+49 221 37970-586
https://www.uk-koeln.de
Application deadline: 26.11.2023

Postal address:
Universitätsklinikum Köln AöR
PA30
Geschäftsbereich Personal